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Que博士是杜克大學(xué)內(nèi)科學(xué)的終身助理教授，在杜克大學(xué)醫(yī)學(xué)中心就職，是美國肺臟協(xié)會的主要研究人員，也是杜克大學(xué)肺病臨床研究組的主任，也是哮喘、過敏和氣道中心的研究主任。曾擔(dān)任美國胸腔協(xié)會主席。

Que博士目前主要研究一氧化氮和相關(guān)酶在肺病發(fā)病機(jī)制中的作用，特別是由亞硝化/氧化應(yīng)激引起的肺部疾病，研究 在細(xì)胞培養(yǎng)中進(jìn)行并應(yīng)用于動物模型，然后在相關(guān)的人類疾病中進(jìn)行。Que博希望通過更好地了解NO和活性氮在介導(dǎo)炎癥和調(diào)節(jié)細(xì)胞信號傳導(dǎo)中的作用，揭示NO相關(guān)肺病的基本機(jī)制，同時為使用NO靶向治療提供理論依據(jù)。

【專長領(lǐng)域】

哮喘

氣道高反應(yīng)

COPD

其他肺病疾病

【教育背景】

1989年于芝加哥大學(xué)取得醫(yī)學(xué)博士學(xué)位

1989-1992于耶魯大學(xué)進(jìn)行住院醫(yī)師培訓(xùn)

1992-1993年于耶魯大學(xué)擔(dān)任臨床導(dǎo)師

1993-1996年于杜克大學(xué)進(jìn)行肺病?？婆嘤?xùn)

【研究資助】(摘選)

· A Longitudinal Prospective Observational Study of the Characteristics, Treatment Patterns and Health Outcomes of Individuals with Severe Asthma in the United States

· CXCL10/CXCR3 regulation of ozone-induced epithelial permeability

· Research Training in Allergy and Clinical Immunology

· Mechanisms that Direct Airway Remodeling in Obese Asthma

· Early Detection of Changes in Pulmonary Gas Exchange by Hyperpolarized Xe MRI

· Interdisciplinary Training Program in Lung Disease

· Trial of Roflumilast in Asthma Management (TRIM)

【學(xué)術(shù)著作】(摘選)

Que, LG, Yang, Z, Lugogo, NL, Katial, RK, Shoemaker, SA, Troha, JM, Rodman, DM, Tighe, RM, and Kraft, M. "Effect of the S-nitrosoglutathione reductase inhibitor N6022 on bronchial hyperreactivity in asthma." Immunity, Inflammation and Disease 6, no. 2 (June 2018): 322-331.

硝基谷胱甘肽還原酶抑制劑N6022對哮喘支氣管高反應(yīng)性的影響

Durack, J, Lynch, SV, Nariya, S, Bhakta, NR, Beigelman, A, Castro, M, Dyer, A-M, Israel, E, Kraft, M, Martin, RJ, Mauger, DT, Rosenberg, SR, Sharp-King, T, White, SR, Woodruff, PG, Avila, PC, Denlinger, LC, Holguin, F, Lazarus, SC, Lugogo, N, Moore, WC, Peters, SP, Que, L, Smith, LJ, Sorkness, CA, Wechsler, ME, Wenzel, SE, Boushey, HA, Huang, YJ, National Heart, and Lung and Blood Institute's “AsthmaNet”, . "Features of the bronchial bacterial microbiome associated with atopy, asthma, and responsiveness to inhaled corticosteroid treatment." The Journal of Allergy and Clinical Immunology 140, no. 1 (July 2017): 63-75.

與過敏、哮喘有關(guān)的支氣管細(xì)菌微生物群的特點(diǎn)及對吸入皮質(zhì)類固醇治療的反應(yīng)

He, M, Driehuys, B, Que, LG, and Huang, Y-CT. "Using Hyperpolarized 129Xe MRI to Quantify the Pulmonary Ventilation Distribution." Academic Radiology 23, no. 12 (December 2016): 1521-1531.

使用超極化 129xeMRI檢查對肺通氣分布定量

Ray, S, Chiba, N, Yao, C, Guan, X, McConnell, AM, Brockway, B, Que, L, McQualter, JL, and Stripp, BR. " Rare SOX2+ Airway Progenitor Cells Generate KRT5+ Cells that Repopulate Damaged Alveolar Parenchyma following Influenza Virus Infection." Stem Cell Reports 7, no. 5 (November 2016): 817-825.

罕見的 sox2 + 氣道祖細(xì)胞產(chǎn)生 krt5 + 細(xì)胞,重新修復(fù)流感病毒感染后受損的肺泡實(shí)質(zhì)。