国产女人香蕉精品视频_国产精品乱人无码伦中文āv一级在线片_AV十八岁在线免费观看_精品成人免费国产_亚洲一区二区三区伊人_两个男生相恋的vlog_香蕉视频下载.apk_日韩一区二区高潮_亚洲日韩欧美内射姐弟_国产亚洲精品A在线观看下载

· 丹娜法伯癌癥研究院女性腫瘤中心乳腺腫瘤中心主任

· 乳腺腫瘤中心臨床研究主任

· 哈佛醫(yī)學(xué)院醫(yī)學(xué)教授

【專長領(lǐng)域】

· 乳腺癌

【教育背景】

1996年：畢業(yè)于約翰霍普金斯大學(xué)醫(yī)學(xué)院

1996 – 1999年：在約翰霍普金斯大學(xué)醫(yī)學(xué)院完成住院醫(yī)師培訓(xùn)

1999 – 2002年：參與丹娜法伯 /合作癌癥治療項(xiàng)目，獲得研究獎(jiǎng)學(xué)金

【研究方向】

乳腺腫瘤的發(fā)生、進(jìn)展、轉(zhuǎn)移和治療，如：Palbociclib聯(lián)合芳香酶抑制劑在新輔助化療中的運(yùn)用;PIK3CA突變與CDK4/6抑制劑之間的相互作用。

【學(xué)術(shù)著作】(摘選)

Obesity promotes resistance to anti-VEGF therapy in breast cancer by up-regulating IL-6 and potentially FGF-2.

Incio J, Ligibel JA, McManus DT, Suboj P, Jung K, Kawaguchi K, Pinter M, Babykutty S, Chin SM, Vardam TD, Huang Y, Rahbari NN, Roberge S, Wang D, Gomes-Santos IL, Puchner SB, Schlett CL, Hoffmman U, Ancukiewicz M, Tolaney SM, Krop IE, Duda DG, Boucher Y, Fukumura D, Jain RK.

Sci Transl Med. 2018 Mar 14;10(432).

肥胖與乳腺癌上調(diào)性IL-6/FGF-2抗VEGF治療的耐藥相關(guān)性分析

Association of Cell-Free DNA Tumor Fraction and Somatic Copy Number Alterations With Survival in Metastatic Triple-Negative Breast Cancer.

Stover DG, Parsons HA, Ha G, Freeman SS, Barry WT, Guo H, Choudhury AD, Gydush G, Reed SC, Rhoades J, Rotem D, Hughes ME, Dillon DA, Partridge AH, Wagle N, Krop IE, Getz G, Golub TR, Love JC, Winer EP, Tolaney SM, Lin NU, Adalsteinsson VA.

J Clin Oncol. 2018 Feb 20;36(6):543-553.

轉(zhuǎn)移性三陰性乳腺癌患者中cfDNA腫瘤分?jǐn)?shù)和體細(xì)胞拷貝數(shù)變化與生存預(yù)后之間的關(guān)系

Low PTEN levels and PIK3CA mutations predict resistance to neoadjuvant lapatinib and trastuzumab without chemotherapy in patients with HER2 over-expressing breast cancer.

Rimawi MF, De Angelis C, Contreras A, Pareja F, Geyer FC, Burke KA, Herrera S, Wang T, Mayer IA, Forero A, Nanda R, Goetz MP, Chang JC, Krop IE, Wolff AC, Pavlick AC, Fuqua SAW, Gutierrez C, Hilsenbeck SG, Li MM, Weigelt B, Reis-Filho JS, Kent Osborne C, Schiff R.

Breast Cancer Res Treat. 2018 Feb;167(3):731-740.

低PTEN水平和PIK3CA突變與拉帕替尼和曲妥珠單抗聯(lián)合治療HER2過度表達(dá)性乳腺癌之間的耐藥相關(guān)性分析

Incidence of Endocrine Dysfunction Following the Use of Different Immune Checkpoint Inhibitor Regimens: A Systematic Review and Meta-analysis.

Barroso-Sousa R, Barry WT, Garrido-Castro AC, Hodi FS, Min L, Krop IE, Tolaney SM.

JAMA Oncol. 2018 Feb 1;4(2):173-182.

不同免疫檢查點(diǎn)抑制劑治療與內(nèi)分泌功能紊亂之間的相關(guān)性分析：系統(tǒng)回顧和薈萃分析