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· 哈佛醫(yī)學(xué)院丹娜法伯癌癥研究院高級(jí)醫(yī)師

· 哈佛醫(yī)學(xué)院助理教授

【專(zhuān)長(zhǎng)領(lǐng)域】

· 肛門(mén)癌

· 膽管癌

· 結(jié)腸癌

· 食管癌

· 膽囊癌

· 胃腸道良性腫瘤

· 肝癌

· 神經(jīng)內(nèi)分泌良性腫瘤

· 胰腺癌

· 直腸癌

· 胃癌

【教育背景】

2000年畢業(yè)于托馬斯杰斐遜大學(xué)醫(yī)學(xué)院，獲得博士學(xué)位

2003年于密歇根大學(xué)醫(yī)學(xué)院完成內(nèi)科學(xué)住院醫(yī)培訓(xùn)

2006年于密歇根大學(xué)醫(yī)學(xué)院完成血液/腫瘤學(xué)專(zhuān)科培訓(xùn)

【從醫(yī)榮譽(yù)】(摘選)

1999年榮獲Hobart Amory Hare Honor Medical Society

2001年榮獲密歇根大學(xué)優(yōu)秀實(shí)習(xí)生

2006年榮獲NIH Ruth L. Kirschstein 國(guó)家研究服務(wù)獎(jiǎng)

【學(xué)術(shù)著作】(摘選)

1. A multicenter phase II trial of single-agent cetuximab in advanced esophageal and gastricadenocarcinoma. Chan JA1, Blaszkowsky LS, Enzinger PC, Ryan DP, Abrams TA, Zhu AX, Temel JS, Schrag D, Bhargava P, Meyerhardt JA, Wolpin BM, Fidias P, Zheng H, Florio S, Regan E, Fuchs CS. Ann Oncol. 2011 Jun;22(6):1367-73. doi: 10.1093/annonc/mdq604. Epub 2011 Jan 7.

單藥西妥昔單抗治療晚期食管癌和胃腺癌的多中心II期臨床試驗(yàn)

2. Patterns of Chemotherapy Use in a U.S.-Based Cohort of Patients with Metastatic Pancreatic Cancer. Abrams TA, Meyer G, Meyerhardt JA, Wolpin BM, Schrag D, Fuchs CS. Oncologist. 2017 Aug;22(8):925-933. doi: 10.1634/theoncologist.2016-0447. Epub 2017 May 5.

美國(guó)轉(zhuǎn)移性胰腺癌患者使用的化療模式

3. A phase 2 and biomarker study of cabozantinib in patients with advanced cholangiocarcinoma. Goyal L, Zheng H, Yurgelun MB, Abrams TA, Allen JN, Cleary JM, Knowles M, Regan E, Reardon A, Khachatryan A, Jain RK, Nardi V, Borger DR, Duda DG, Zhu AX. Cancer. 2017 Jun 1;123(11):1979-1988. doi: 10.1002/cncr.30571. Epub 2017 Feb 13.

卡博替尼蘋(píng)果酸鹽在晚期膽管癌患者中生物標(biāo)志物的Ⅱ期研究

4. A phase I and pharmacokinetic study of ganetespib (STA-9090) in advanced hepatocellular carcinoma. Goyal L, Wadlow RC, Blaszkowsky LS, Wolpin BM, Abrams TA, McCleary NJ, Sheehan S, Sundaram E, Karol MD, Chen J, Zhu AX. Invest New Drugs. 2015 Feb;33(1):128-37. doi: 10.1007/s10637-014-0164-8. Epub 2014 Sep 24.

Ganetespib在晚期肝細(xì)胞癌患者中的藥代動(dòng)力學(xué)Ⅰ期研究

5. Delaying chemoradiation until after completion of adjuvant chemotherapy for pancreatic cancer may not impact local control. Wo JY, Childs SK, Szymonifka J, Mamon HJ, Ryan DP, Blaszkowsky LS, Kwak EL, Ferrone CR, Allen JN, Zhu AX, Wolpin BM, Chan JA, Abrams TA, McCleary NJ, Fernandez-del Castillo C, Hong TS. Pract Radiat Oncol. 2014 Mar-Apr;4(2):e117-23. doi: 10.1016/j.prro.2013.07.006. Epub 2013 Aug 9.

胰腺癌患者完成輔助化療后才結(jié)束放化療可能不會(huì)影響病灶的局部控制

6. Multi-drug inhibition of the HER pathway in metastatic colorectal cancer: results of a phase I study of pertuzumab plus cetuximab in cetuximab-refractory patients. Rubinson DA, Hochster HS, Ryan DP, Wolpin BM, McCleary NJ, Abrams TA, Chan JA, Iqbal S, Lenz HJ, Lim D, Rose J, Bekaii-Saab T, Chen HX, Fuchs CS, Ng K. Invest New Drugs. 2014 Feb;32(1):113-22. doi: 10.1007/s10637-013-9956-5. Epub 2013 Apr 9.

轉(zhuǎn)移性結(jié)直腸癌中HER途徑的多藥物抑制：對(duì)西妥昔單抗難治性患者使用帕妥珠單抗聯(lián)合西妥昔單抗的I期研究結(jié)果