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· 哈佛大學(xué)丹娜法伯癌癥研究院免疫效應(yīng)細(xì)胞治療項(xiàng)目醫(yī)學(xué)主管

· 哈佛醫(yī)學(xué)院講師

【專(zhuān)長(zhǎng)領(lǐng)域】

· 慢性髓系白血病

· 霍奇金淋巴瘤

· 非霍奇金淋巴瘤

【研究方向】

· CAR-T

· 淋巴瘤

【教育背景】

2004年畢業(yè)于哥倫比亞大學(xué)醫(yī)學(xué)院，獲得博士學(xué)位

2008年于紐約長(zhǎng)老會(huì)醫(yī)學(xué)院完成實(shí)習(xí)和內(nèi)科學(xué)住院醫(yī)培訓(xùn)

2011年于丹娜法伯癌癥研究所完成血液/腫瘤學(xué)專(zhuān)科培訓(xùn)

【學(xué)術(shù)著作】(摘選)

1. Autologous Stem Cell Transplantation in Elderly Lymphoma Patients in Their 70s: Outcomes and Analysis. Sun L, Li S, El-Jawahri A, Armand P, Dey BR, Fisher DC, Jacobsen ED, Jacobson CA, LaCasce AS, McAfee SL, Spitzer TR, Chen YB, DeFilipp Z. Oncologist. 2017 Dec 28. pii: theoncologist.2017-0499. doi: 10.1634/theoncologist.2017-0499.

70幾歲的淋巴瘤老年患者接受自體干細(xì)胞移植治療的療效和分析

2. Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma. Neelapu SS, Locke FL, Bartlett NL, Lekakis LJ, Miklos DB, Jacobson CA, Braunschweig I, Oluwole OO, Siddiqi T, Lin Y, Timmerman JM, Stiff PJ, Friedberg JW, Flinn IW, Goy A, Hill BT, Smith MR, Deol A, Farooq U, McSweeney P, Munoz J, Avivi I, Castro JE, Westin JR, Chavez JC, Ghobadi A, Komanduri KV, Levy R, Jacobsen ED, Witzig TE, Reagan P, Bot A, Rossi J, Navale L, Jiang Y, Aycock J, Elias M, Chang D, Wiezorek J, Go WY. N Engl J Med. 2017 Dec 28;377(26):2531-2544. doi: 10.1056/NEJMoa1707447. Epub 2017 Dec 10.

Axicabtagene Ciloleucel CAR-T細(xì)胞治療難治性大B細(xì)胞淋巴瘤

3. Relapsed or Refractory Double-Expressor and Double-Hit Lymphomas Have Inferior Progression-Free Survival After Autologous Stem-Cell Transplantation. Herrera AF, Mei M, Low L, Kim HT, Griffin GK, Song JY, Merryman RW, Bedell V, Pak C, Sun H, Paris T, Stiller T, Brown JR, Budde LE, Chan WC, Chen R, Davids MS, Freedman AS, Fisher DC, Jacobsen ED, Jacobson CA, LaCasce AS, Murata-Collins J, Nademanee AP, Palmer JM, Pihan GA, Pillai R, Popplewell L, Siddiqi T, Sohani AR, Zain J, Rosen ST, Kwak LW, Weinstock DM, Forman SJ, Weisenburger DD, Kim Y, Rodig SJ, Krishnan A, Armand P. J Clin Oncol. 2017 Jan;35(1):24-31. Epub 2016 Oct 24.

復(fù)發(fā)或難治性雙表達(dá)和雙重打擊淋巴瘤自體干細(xì)胞移植后無(wú)進(jìn)展生存期較差

4. Idelalisib given front-line for treatment of chronic lymphocytic leukemia causes frequent immune-mediated hepatotoxicity. Lampson BL, Kasar SN, Matos TR, Morgan EA, Rassenti L, Davids MS, Fisher DC, Freedman AS, Jacobson CA, Armand P, Abramson JS, Arnason JE, Kipps TJ, Fein J, Fernandes S, Hanna J, Ritz J, Kim HT, Brown JR. Blood. 2016 Jul 14;128(2):195-203. doi: 10.1182/blood-2016-03-707133. Epub 2016 May 31.

將艾德拉尼作為慢性淋巴細(xì)胞白血病的一線用藥會(huì)引起頻繁的免疫介導(dǎo)的肝毒性

5. Detection of activating MAP2K1 mutations in atypical hairy cell leukemia and hairy cell leukemia variant. Mason EF, Brown RD, Szeto DP, Gibson CJ, Jia Y, Garcia EP, Jacobson CA, Dal Cin P, Kuo FC, Pinkus GS, Lindeman NI, Sholl LM, Aster JC, Morgan EA. Leuk Lymphoma. 2017 Jan;58(1):233-236. Epub 2016 May 31.

在非典型性毛細(xì)胞白血病和毛細(xì)胞白血病變體中檢測(cè)激活的MAP2K1突變