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· 哈佛大學丹娜法伯癌癥研究院成人白血病臨床與轉化研究主任

· 哈佛醫(yī)學院教授

【專長領域】

· 急性淋巴細胞白血病

· 急性髓系白血病

· 慢性髓系白血病

· 骨髓增生異常/骨髓增生性疾病

【教育背景】

1993年畢業(yè)于阿爾伯愛因斯坦醫(yī)學院，取得博士學位

1996年于麻省總院完成住院醫(yī)培訓

1999年于丹娜法伯癌癥研究院完成血液/腫瘤學?？婆嘤?/p>

【從醫(yī)榮譽】(摘選)

2014，2015，2018年榮獲“最富同情心醫(yī)生”稱號

2018年榮獲“準時醫(yī)生”獎

2012，2018年榮獲“患者選擇”獎

【研究方向】

· CAR-T

· 白血病

· 肥大細胞增多癥

· 骨髓增生異常綜合征

· 骨髓增生性疾病

【學術著作】(摘選)

1. Cortes JE, Kim DW, Pinilla-Ibarz J, le Coutre PD, Paquette R, Chuah C, Nicolini FE, Apperley JF, Khoury HJ, Talpaz M, DeAngelo DJ, Abruzzese E, Rea D, Baccarani M, Müller MC, Gambacorti-Passerini C, Lustgarten S, Rivera VM, Haluska FG, Guilhot F, Deininger MW, Hochhaus A, Hughes TP, Shah NP, Kantarjian HM. Ponatinib efficacy and safety in Philadelphia chromosome-positive leukemia: final 5-year results of the phase 2 PACE trial. Blood. 2018 Mar 22.

普納替尼在費城染色體陽性白血病中的療效和安全性：2期PACE試驗的最終5年結果

2. Wagner FF, Benajiba L, Campbell AJ, We?wer M, Sacher JR, Gale JP, Ross L, Puissant A, Alexe G, Conway A, Back M, Pikman Y, Galinsky I, DeAngelo DJ, Stone RM, Kaya T, Shi X, Robers MB, Machleidt T, Wilkinson J, Hermine O, Kung A, Stein AJ, Lakshminarasimhan D, Hemann MT, Scolnick E, Zhang YL, Pan JQ, Stegmaier K, Holson EB. Exploiting an Asp-Glu "switch" in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia. Sci Transl Med. 2018 Mar 07; 10(431).

利用糖原合成酶激酶3中的Asp-Glu“開關”來研發(fā)用于急性骨髓性白血病的旁系同源物選擇性抑制劑

3. Luskin MR, DeAngelo DJ. How to treat chronic myeloid leukemia (CML) in older adults. J Geriatr Oncol. 2018 Feb 18.

如何治療慢性髓系白血病老年患者

4. Siegel SE, Stock W, Johnson RH, Advani A, Muffly L, Douer D, Reed D, Lewis M, Freyer DR, Shah B, Luger S, Hayes-Lattin B, Jaboin JJ, Coccia PF, DeAngelo DJ, Seibel N, Bleyer A. Pediatric-Inspired Treatment Regimens for Adolescents and Young Adults With Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia: A Review. JAMA Oncol. 2018 Feb 15.

受兒童治療方案費城染色體陰性急性淋巴細胞白血病的青少年和年輕成人

5. Grace RF, DeAngelo DJ, Stevenson KE, Neuberg D, Sallan SE, Mourad YRA, Bergeron J, Seftel MD, Kokulis C, Connors JM. The use of prophylactic anticoagulation during induction and consolidation chemotherapy in adults with acute lymphoblastic leukemia. J Thromb Thrombolysis. 2018 Feb; 45(2):306-314.

在急性淋巴細胞白血病成人患者誘導和鞏固化療期間使用預防性抗凝治療

6. Stein EM, Walter RB, Erba HP, Fathi AT, Advani AS, Lancet JE, Ravandi F, Kovacsovics T, DeAngelo DJ, Bixby D, Faderl S, Jillella AP, Ho PA, O'Meara MM, Zhao B, Biddle-Snead C, Stein AS. A phase 1 trial of vadastuximab talirine as monotherapy in patients with CD33-positive acute myeloid leukemia. Blood. 2018 Jan 25; 131(4):387-396.

Vadastuximab talirine單藥治療CD33陽性急性髓系白血病的Ⅰ期試驗

7. DeAngelo DJ, Brunner AM, Werner L, Avigan D, Fathi AT, Sperling AS, Washington A, Stroopinsky D, Rosenblatt J, McMasters M, Luptakova K, Wadleigh M, Steensma DP, Hobbs GS, Attar EC, Amrein PC, Ebert BL, Stone RM, Ballen KK. A phase I study of lenalidomide plus chemotherapy with mitoxantrone, etoposide, and cytarabine for the reinduction of patients with acute myeloid leukemia. Am J Hematol. 2018 Feb; 93(2):254-261.

來那度胺聯(lián)合米托蒽醌+依托泊苷+阿糖胞苷化療用于急性髓細胞白血病患者的再次誘導治療的I期試驗